Bio-Data

 

Name

Raman K. Verma

 

 

Father's Name

Sh. Nand Kishore "Rajneesh"

 

 

Date of Birth

1st October, 1958

 

 

Address

Office

Synthetic Organic and Medicinal Chemistry Laboratory

Synthesis and CombiChem Lab

in silico drug design Lab

Department of Chemistry,

Punjabi University, Patiala - 147 002 (Pb) INDIA

 

 

Residence

Aastha Villa

8A Street 9 North Avenue

Bhadson Road Patiala – 147 001 (pb) INDIA

 

 

Phone:

9915736061

 

 

e-mail

raman_verma58@yahoo.com

 

Academics

 

Exam Passed

Board/University

Year Of Passing

Marks (%)

 

 

 

 

Ph.D.

Punjabi University, Patiala

1987

 

 

 

 

 

M. Phil.

Punjabi University, Patiala

1982

4.626 (Gr. A)

 

 

 

 

M. Sc. (Org. Chem.)

Punjabi University, Patiala

1981

66.521

 

 

 

 

B. Sc. (Med.)

Punjabi University, Patiala

1978

71.384

 

Teaching and Research Experience

 

Topic of the Ph.D. Thesis

Esterification through O-alkylation: Synthetic and Mechanistic Studies

 

 

Teaching Experience

Undergraduate classes : 18 years

 

 

 

Postgraduate classes : 12 years

 

 

Research Experience

 

After M. Sc.

6 years

 

 

After Ph.D.

20 years

 

 

 

M.Pharm: 8 years*

 

 

 

Doctorate: 5 years*

 

 

Area of Specialization

 

Major

Synthetic Organic and Medicinal Chemistry

 

 

Minor

in silico Drug Design (Computational Validation of NCEs)

 

LIST OF PUBLICATIONS

 

RESEARCH PAPERS

 

1.         Esterification at room temperature: A Mixing affair only.

Baldev Kumar and Raman K Verma

Synthetic Communications. 1984, 14, 1359-1363.

 

2.         Esterification of maleanilic Acids: Intramolecular

esterification through imidate ester.

Baldev Kumar, Raman K Verma and Harjit Singh

Indian Journal of Chemistry. 1986, 25B, 692-696.

 

3.         N-Aryl-a-chlorosuccinimide from maleanilic acids:Mechanistic and conformational studies.

Raman K Verma and Baldev Kumar

Indian Journal of Chemistry. 1991, 30B, 822-824.

 

4.         1H NMR Spectra (52463M-52465M), IR Spectra (79495K-79497K).

Baldev Kumar and Raman K Verma

            Biorad Sadtler Division. 1991, Philadelphia PA: Sadtler Research Laboratories

 

5.         A Facile and high yield route to succinanilic esters.

Raman K Verma

Journal of Indian Chemical Society. 1992, 69, 683-684.

 

6.         A Simple and convenient synthesis of alkyl succinanilates

Raman K Verma

Asian Journal of Chemistry 1993, 5, 1137-1139.

 

7.         Synthesis of 2-substituted-[(2'-carboxybiphenyl-4-yl)methyl]benzimidzoles

Preet Mohinder Singh Bedi, Raman K Verma and Manjeet Singh

Indian Journal of Chemistry. 1998, 37B, 801-803.

 

8.         Calcium conjugates of amino acids as plant growth regulators

R. K. Verma, R. K. Sharma, V. L. Maheshwari & R. M. Kothari

Journal of Plant Biology. 2000, 27, 85-88.

 

9.         A facile synthesis of 2-Benzyloxy/2-(4-isopropylbenzyloxy)-2-methyl-3-(4-substituted     phenyl)propanoic acid based insulin sensitizing agents: RSR13-15 and PKR13-15.

Raman K Verma, Rubina Singla and V. T. Punniyakoti          

             Medicinal Chemistry Research. 2004,13,660-676.

 

10.       A facile and new approach to biologically significant and functionalisable heterobiaryls

Raman K Verma, Monika Aggarwal, Manisha Bansal and Inder Preet Kaur

             Synthetic Communications. 2007,37,1-6.

 

11.       A facile and new approach to synthesize 2-amino-4-(4-aminophenyl)-1h-1,3-diazol-1-yl-     alkylaminomethanethiones

Raman K Verma, Monika Aggarwal, Manisha Bansal and Inder Preet Kaur

             Medicinal Chemistry Research. 2007,15,483-491.

 

12.       Lipase and Ca2+ Ions as biomarkers in blood serum of NIDDM

Verma N, Mittal M, Verma R K

Journal of Clinical and Diagnostid Research. 2008. 2. 942-945.

 

13.       Docking of oxalyl aryl amino benzoic acids derivatives into PTP1B

            Neelem Verma, Meenakshi Garg and Raman Kumar Verma

            Bioinformation. 2008, 3(2), 83-88.

 

14.       QSAR studies on structurally similar oxalyl aryl amino benzoic acid derivatives as antidiabetic agents

Verma N, Mittal M, Verma R K

Calicut Medical Journal. 2008, 6(4): e3 1-11          

 

ARTICLES

 

1.         Hereditary Predisposition to Malignancies

Raman K Verma

New Horizons in Human Biology

Editor I J S Bansal et al, 55-58 (1991)

Today and Tomorrow Printers and Publishers, New Delhi-110 005

 

2.         NMR-A Boon for the Organic Chemist

Raman K Verma

IX Refresher Course in Chemistry

ACS and Dept. of Chemistry, Punjab University Chandigarh.

Abstracts of lectures p46(March-April 1994).

 

CONFERENCES, SYMPOSIA, WORKSHOPS AND RELATED

A. International

 

1.   Esterification reactions of Maleanilic Acids: Synthetic and Mechanistic Approach

10th IUPAC International Conference on Organic Synthesis (ICOS -10)

Indian Institute of Science, Banglore (December 11-16, 1994)

 

2. A mixing affair package to useful derivatives of meleanilic acids at room temperature

20th  IUPAC Symposium on the chemistry of natural products

Chicago IL USA (September 15-20, 1996)

 

3. Facile Synthesis of 2-Substituted Benzimidazole Analogues of EXP 7711 Angiotensin II Receptor Antagonists

7th Kyoto Conference of Organic Chemistry (IKCOC-7)

Osaka Japan (November 10-14, 1997)

 

4.     A Newer and efficient synthesis of 3-Aryl-2-Aryloxypropanoic acid based insulin sensitizing agents

International Symposium on the Drug Discovery Paradigm

Cambridge Health Tech Institute, USA and Astra Research Centre, Bangalore

Indian Institute of Science, Bangalore, India (September15-17, 1999)

 

5.     Attended

International Symposium on Bioinformatics and Genomics

Confederations of Indian Industries, Karnataka Office

Indian Institute is Science, Bangalore, India (January15-17, 2001)

 

6.     N-Alkyl-N'-(3,5-dibromo-4-hydroxy)benzylguanidine based centrally acting antihypertensive agents

International Symposium on Progress in Drug Discovery and Development Sciences

Astra Zeneca Research Foundation, Bangalore, India

Indian Institute of Science, Bangalore, India (January17-19, 2001)

 

7. Facile Synthesis of Suitably Substituted 2-Aminoimidazoles and 2-Aminoimidazolines as      Expected Antiasthmatic Agents

10th Symposium on the Latest Trends in Organic Synthesis (LTOS -10)

      Gainesville, Florida,   USA. (October 23-26, 2002)

 

8.   A Facile Synthesis of 2-[(Substituted benzyl)imino/amino]imidazolidine/imidazoline based centrally acting antihypertensive agents

      IUPAC International conference on Biodiversity and natural Products: Chemistry and Medical applications (ICOB-4 and ISCNP-24)

      Hotel Le Meridian, New Delhi, India (January 26-31, 2004)

 

9.   A facile synthesis of 2-Benzyloxy/2-(4-isopropylbenzyloxy)-2-methyl-3-(4-substituted     phenyl)propanoic acid based insulin sensitizing agents: RSR13-15 and PKR13-15.

      2nd International Symposium

      Current Trends In drug Discovery Research (CTDDR - 2004)

      CDRI, Lucknow, India (February 17-20, 2004)

 

10. Design and Synthesis of 4-(cyclicimido)-phenyl containing 2-amino-2-imidazoline and alkylguanidine based new and biologically significant ligands.

International conference On Chemistry Biology Interface: synergistic New Frontiers (CBISNF 2004)

      Vigyan Bhaban, New Delhi, India (November 21-26, 2004)

 

Research Work in collaboration with Centre for Pharmacoinformatics (NIPER)

 

11a.Ideal Synthesis and Comparative Alignment Studies Of Phenylpyridine And Phenylpyridopyrimidine Based Compounds With Expected Antiasthmatic Activity

      Raman K. Verma*, M Elizabeth Sobhia†,  Monika Aggarwal, Manisha Bansal and  Inder Preet Kaur

 

11b.Synthesis and 3D QSAR Studies Of 2-Aminoimidazolines And Their Isosteres As Central α2 -Adrenoceptor Agonists

Raman K. Verma*, M Elizabeth Sobhia†, Manisha Bansal, Monika Aggarwal and

Inder Preet Kaur

 

11c. 3D QSAR Studies On Newly Designed Phenylpropanoic Acid Based PPARγ Agonists As Potent Insulin Sensitizers

Raman K. Verma*, M Elizabeth Sobhia†, Inder Preet Kaur, Manisha Bansal and Monika Aggarwal

      3nd International Symposium

Current Trends In drug Discovery Research (CTDDR 2007)

      CDRI, Lucknow, India (February 17-21, 2007)

 

CONFERENCES, SYMPOSIA, WORKSHOPS AND RELATED

B. National

 

1.         Radiation and Chemical Mutagens

NCCYSRF, Punjabi University, Patiala (January 17-19, 1989)

 

2.         NMR-A Diagnostic Aid: Present and Future Prospectives

UGC Seminar on Biotechnology, Punjabi University, Patiala (March 14-15, 1989)

 

3.         Hereditary Predisposition to Malignancies

UGC Seminar on New Horizon in Human Biology, Punjabi University, Patiala

(November 9-10, 1989)

 

4.         Attended

Short Term Course on Instrumental Analysis. Chemical Engineering Division, TCRDC, Patiala (November 26-30, 1990)

 

5.         NMR Study of Some N-(o-and m-substituted) Aryl-a-chlorosuccinimides.

National Seminar on Newer Methods of Synthesis in Chemistry.

Punjabi University, Patiala (October 27-29, 1993)

 

6.     Attended

5th National Workshop on Mass Spectrometery

(5thNWMS)ISMAS-BARC Bombay Sponsored

RSIC, Punjab University, Chandigarh (April 19-26, 1994)

 

7.         Derivation of Maleanilic Acids: Synthetic, Mechanistic and Stereochemical Approach

83rd Indian Science Congress

Punjabi University, Patiala (January 1996)

 

8.         Attended

Summer School on Computer Aided Drug Design

National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali, Punjab (June 15-19, 1998)

 

9.                  Attended

 3rd National Symposium in Chemistry (NSC-3),

Chemical Research Society of India (CRSI), Bangalore Sponsored

Department of Chemistry and Centre for Advanced Studies in Chemistry, Panjab University, Chandigarh (February 2-4, 2001)

 

10.              Attended

Workshop On Pharmacoinformatics In Drug Design

National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali, Punjab (April14-16, 2005)

 

11.       Attended

Workshop on Pharmacoinformatics: QSAR

National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali, Punjab (March 1-3, 2006)

12.       Attended

Workshop on Pharmacoinformatics: Structure Based Drug Design

National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali, Punjab (March 13-15, 2008)

 

13.     Invited Talk

 

NDDR: Rational Drug Design and Combinatorial Chemistry

Raman K Verma

National Symposium on Recent Trends in Chemistry - 2009

January 20-21, 2009 Department of Chemistry, Punjabi University, Patiala.

 

14.       Co-Chairperson

            National Conference on Innovations in Drug Discovery and Research

            Department of Pharmaceutical sciences and drug research

Punjabi University, Patiala

Punjab (March 3-5, 2009)

 

RESEARCH WORK GUIDED/GUIDING

(I) M. Pharm. Thesis Guided:           15

(II) Ph.D Thesis guided: 2

(III) Registered: 2 (Supervisor)

(IV) Enrolled: 2 (Supervisor) ISLL-Punjabi University: Collaborative Research

RESEARCH PROJECTS AND RELATED

Handled

ü      A CONVENIENT SYNTHESIS OF b-THIOAMIDO-a,b-UNSATURATED ESTERS AND THIOESTERS: MECHANISTIC & BIOLOGICAL ACTIVITY STUDIES, 1989-91 (UGC NEW DELHI).

ü      PHOTOCHEMISTRY OF PESTICIDES AND SOIL TREATMENT AGENTS ON SOLID SURFACES-SOILS AND SILICA GEL: A COMPARATIVE STUDY, 1994-96 (UGC NEW DELHI).

ü      SUBSTITUTED 4-THIAZOLIDINONES AND 2-AZETIDINONES: SYNTHETIC AND BIOLOGICAL ACTIVITY STUDIES 1998-2000 (UGC UNASSIGNED GRANT, PUNJABI UNIVERSITY, PATIALA).

Collaborated

ü      SYNTHESIS OF SUPER PLANT GROWTH REGULATORS, BIOTECHNOLOGY DIVISION, THAPAR CORPORATE R & D CENTER, PATIALA

ü      APPLICATION OF SOME HETEROPOLY ACID SALTS AS CATALYSTS IN THE ESTERIFICATION REACTIONS, DEPARTMENT OF CHEMISTRY, THAPAR INSTITUTE OF ENGINEERING AND TECHNOLOGY, PATIALA

Handling

ISLL-Punjabi University: Collaborative Research*

DESIGN SYNTHESIS AND COMPUTATIONAL VALIDATION OF MEDICINALLY SIGNIFICANT NEW CHEMICAL ENTITIES (NCEs)

 

Others

Ø      Recipient of Punjabi University award for Improvement of Education research work in colleges, 1987-88.

 

Ø      Recipient of Punjabi University award for Improvement of Education research work in colleges, 1991-92.

 

* Punjabi University, Patiala and Ind-swift Laboratories Ltd, Research and Development Centre,Mohali has signed general and confidentiality agreements to carry out collaborative research in two major areas of therapeutic significance.

MEMBERSHIP OF VARIOUS SOCIETIES

 

1.      Indian Society For Mass Spectrometry

Life Membership No. of ISMAS : L – 358

 

2.      American Chemical Society

Membership No. for year 2000 : 2269533

 

3.      Indian Society For Radiation and Photochemical Sciences

      Life Membership No. of ISRAPS : L – 141